Phenotypes Associated with This Genotype

Genotype
MGI:3714469

• Allelic Composition: Myf5^tm1Jae/Myf5⁺; Myf6^tm1Eno/Myf6⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:42453 )

• 63% of double heterozygous mice, in which the Myf5 and Myf6 alleles are on different chromosomes and show severely reduced expression of Myf5, die immediately after birth; the rest survive

skeleton

abnormal sternocostal joint morphology ( J:42453 )

• attachment failure of at least one rib to the sternum is seen in most mutants, although the identity of the affected rib(s) and the number of ribs affected varies

abnormal rib morphology ( J:42453 )

• abnormal ribs

muscle

abnormal myotome development ( J:42453 )

• number of myocytes in the myotomes is reduced at E10.5 and the conformation of the myotome is abnormal