Phenotypes Associated with This Genotype

Genotype
MGI:3714502

• Allelic Composition: Myf6^tm1Eno/Myf6^tm1Eno; Myog^tm1Whk/Myog^tm1Whk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• lethality at birth; mutants exhibit reduced levels of Myf5 mRNA unlike single Myf6^tm1Eno homozygotes

muscle

abnormal muscle fiber morphology ( J:48809 )

• exhibit a deficiency in muscle fibers showing only residual differentiated muscle fibers, however the number of these residual fibers is similar to that seen in Myog homozygotes

muscle hypoplasia ( J:48809 )

• exhibit a deficiency in muscle fibers

skeleton

abnormal sternebra morphology ( J:48809 )

• sternebral bodies are severely malformed

abnormal sternocostal joint morphology ( J:48809 )

• distal portions of the ribs fail to reach the sternum

split sternum ( J:48809 )

• upper region of the sternum is bifurcated