Analysis Tools
vision/eye
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• the total number of axons is reduced and many of the axons that reach the optic chiasm are abnormal and misrouted dorsally to the hypothalamus or occasionally to the optic nerve of the other eye
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• while the number of retinal ganglion cells are decreased the number of displaced amacrine cells is increased threefold
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• the number of displaced amacrine cells is increased threefold
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• neurons from the retinal ganglion cell (RGC) layer have abnormal neurite outgrowths in vitro, suggestive of dendrites rather than axons
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• at 3 weeks, retinal ganglion cell number of the ventral-temporal region is 85% of the cells found in wild-type
• overall, retinal ganglion cells in the retina are reduced by 65%
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• the retinal ganglion cell (RGC) layer is composed of 6+/-2 RGCs with two-thirds of the layer being composed of amacrine cells compared to wild-type RGC layer which are composed of 15+/-3 RGCs and the layer of one third amacrine cells
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• at E16.5 and 3 weeks, fewer optic fibers form and those present are entangled and cross or by-pass the optic disk
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nervous system
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• at E16.5 and 3 weeks, fewer optic fibers form and those present are entangled and cross or by-pass the optic disk
• at 3 weeks, a larger proportion of axons are directed ipsilaterally increasing the ipsilateral/contralateral ratio to almost 1.0
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• the number of displaced amacrine cells is increased threefold
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• neurons from the retinal ganglion cell (RGC) layer have abnormal neurite outgrowths in vitro, suggestive of dendrites rather than axons
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• at 3 weeks, retinal ganglion cell number of the ventral-temporal region is 85% of the cells found in wild-type
• overall, retinal ganglion cells in the retina are reduced by 65%
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• the total number of axons is reduced and many of the axons that reach the optic chiasm are abnormal and misrouted dorsally to the hypothalamus or occasionally to the optic nerve of the other eye
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