Phenotypes Associated with This Genotype

Genotype
MGI:3714533

• Allelic Composition: Myf6^tm1Eno/Myf6^tm1Eno; Myod1^tm1Jae/Myod1^tm1Jae; Myog^tm1Whk/Myog^tm1Whk
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:61155 )

• die within minutes of birth

growth/size/body

decreased fetal size ( J:61155 )

• E18.5 mutants show a reduction in body mass

muscle

abnormal muscle development ( J:61155 )

• marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers

• myoblasts from neonates are unable to differentiate in vitro

muscle hypoplasia ( J:61155 )

• severe muscle deficiency with almost no muscle fibers; the few fibers that are present are extremely thin and underdeveloped

• tongue, back, limb, and skeletal muscle are all affected comparably unlike in single Myog homozygous mutants

skeleton

abnormal rib morphology ( J:61155 )

• the average lengths of the ossified portions of the ribs are 30% shorter than normal at E15.5, however the ribs reach the sternum

kyphosis ( J:61155 )

• severe