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Phenotypes Associated with This Genotype
Genotype
MGI:3714659
Allelic
Composition		 Grb2tm1Paw/Grb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1Paw mutation (0 available); any Grb2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Retroviridae infection ( J:122429 )
• mice exhibit reduced susceptibility to Friend erythroleukemia virus (FV)
• spleen size following FV infection is not as inflamed as in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory