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Phenotypes Associated with This Genotype
Genotype
MGI:3714954
Allelic
Composition		 Cacna2d1tm1Cptl/Cacna2d1tm1Cptl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna2d1tm1Cptl mutation (0 available); any Cacna2d1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:117098 )
• dorsal root ganglion neuron CaV2.2 currents exhibit a small enhancement with an enhanced peak current

behavior/neurological
impaired behavioral response to xenobiotic ( J:117098 )
• pregabalin is ineffective in blocking pain behavior following formalin testing

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory