Phenotypes Associated with This Genotype

Genotype
MGI:3716105

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:100886 )

• neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3

increased sensory neuron number ( J:100886 )

• apoptosis rates are decreased resulting in increased number of neurons in the lumbar dorsal root ganglia (170% of wild-type numbers)

abnormal dorsal root ganglion morphology ( J:100886 )

• dorsal root ganglia neurons survive without neurotrophic factors

cellular

abnormal axon extension ( J:100886 )

• neurite outgrowth is significantly less than that of Isl1^tm1(cre)Cos Mapt^{tm1(Ewsr1/Etv4)Arbr} heterozygotes with or without treatment with neurotrphin-3