Phenotypes Associated with This Genotype

Genotype
MGI:3716392

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Prm-cre)58Og/0
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119477 )

• mutants die between E9.5 and 11.5

embryo

absent vitelline blood vessels ( J:119477 )

• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent

increased embryonic tissue cell apoptosis ( J:119477 )

• at death, embryos exhibit widespread apoptosis

embryonic growth arrest ( J:119477 )

• embryos show developmental arrest

abnormal placenta labyrinth morphology ( J:119477 )

• marked defect in inner labyrinth layer is observed at E9.5

abnormal placental labyrinth vasculature morphology ( J:119477 )

• fetal blood vessels underlying inner labyrinth layer are absent

pale yolk sac ( J:119477 )

• at E9.5, yolk sacs are pale and roughened

cellular

increased embryonic tissue cell apoptosis ( J:119477 )

• at death, embryos exhibit widespread apoptosis

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:119477 )

• fetal blood vessels underlying inner labyrinth layer are absent

absent vitelline blood vessels ( J:119477 )

• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent