Phenotypes Associated with This Genotype

Genotype
MGI:3716770

• Allelic Composition: Agrn^tm1Rwb/Agrn^tm1Rwb; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:122821 )

N • when compared to normal controls, no pathological changes are detected until at least 8 months of age

N • glomerular filtration barrier is not compromised in mutants, with normal urinary protein and creatinine levels up to 10 months of age when compared to controls

abnormal renal glomerulus basement membrane morphology ( J:122821 )

• at ~4 months of age, glomerular basement membrane (GBM) abnormalities including focal thickening and epithelial protrusions of GBM material are observed in mutants

increased renal glomerulus basement membrane thickness ( J:122821 )

• focal thickening of the GBM is noted at ~4 months of age