Phenotypes Associated with This Genotype

Genotype
MGI:3716820

• Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm; Tg(Lck-cre)548Jxm/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:97484 )

• mice have increased mortality following treatment with a CD3epsilon antibody

• mortality increases following treatment with staphylococcal enterotoxin A (SEA)

• however, treatment with CD3epsilon antibody or staphylococcal enterotoxin A (SEA) and a COX-2 inhibitor reverses the increase in mortality

immune system

cecum inflammation ( J:97484 )

• treatment with a CD3epsilon antibody leads to inflammation of the cecum

abnormal interferon level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, interferon-gamma levels are increased

abnormal interleukin level ( J:97484 )

• 8 hours after CD3epsilon antibody treatment, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, TNF-alpha levels are increased

increased susceptibility to endotoxin shock ( J:97484 )

• mortality increases following treatment with staphylococcal enterotoxin A (SEA)

digestive/alimentary system

abnormal cecum morphology ( J:97484 )

• treatment with a CD3epsilon antibody leads to increased gastrointestinal damage in the cecum including mucosal and submucosal edema and inflammation along with necrotic regions that are denuded of mucosa

cecum inflammation ( J:97484 )

• treatment with a CD3epsilon antibody leads to inflammation of the cecum

homeostasis/metabolism

abnormal interferon level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, interferon-gamma levels are increased

abnormal interleukin level ( J:97484 )

• 8 hours after CD3epsilon antibody treatment, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:97484 )

• 2 hours after CD3epsilon antibody treatment, TNF-alpha levels are increased