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Phenotypes Associated with This Genotype
Genotype
MGI:3716826
Allelic
Composition
Nr3c1tm2Ljm/Nr3c1tm2Ljm
Tg(Camk2a-cre)T50Stl/?
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Ljm mutation (0 available); any Nr3c1 mutation (35 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• peak and basal corticosterone levels are increased at 6 months of age

behavior/neurological
• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair
• however, despair behaviors are reversed by chronic treatment with the tricyclic antidepressant imipramine
• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair

nervous system
• low-frequency stimulation in the presence of 1um corticosterone of hippocampal slices can not induce long term depression (LTD)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory