Phenotypes Associated with This Genotype

Genotype
MGI:3716826

• Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm; Tg(Camk2a-cre)T50Stl/?
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating corticosterone level ( J:96260 )

• peak and basal corticosterone levels are increased at 6 months of age

behavior/neurological

behavioral despair ( J:96260 )

• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair

• however, despair behaviors are reversed by chronic treatment with the tricyclic antidepressant imipramine

decreased locomotor activity ( J:96260 )

• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair

nervous system

absent long-term depression ( J:96260 )

• low-frequency stimulation in the presence of 1um corticosterone of hippocampal slices can not induce long term depression (LTD)