Phenotypes Associated with This Genotype

Genotype
MGI:3716860

• Allelic Composition: Rps6ka5^tm1Jsca/Rps6ka5^tm1Jsca
• Genetic Background: B6.Cg-Rps6ka5^tm1Jsca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:123042 )

• although mice experience a hyperlocomotor phase following initial exposure to cocaine no continued increase in locomotor activities is seen with repeated administration of the drug

enhanced conditioned place preference behavior ( J:123042 )

• mice are conditioned at lower doses (10mg/kg) of cocaine and after conditioning spent significantly more time in the cocaine-associated side

• mice showed no increased response at 20mg/kg