Phenotypes Associated with This Genotype

Genotype
MGI:3717274

• Allelic Composition: Grb2^tm1Paw/Grb2⁺; Pten^tm1Mak/Pten⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:93530 )

mortality/aging

mortality/aging ( J:93530 )

N • the embryonic lethality seen in Pten^tm1Mak heterozygotes is completely rescued

neoplasm

increased tumor incidence ( J:93530 )

• develop the same tumor types at the same frequency as Pten^tm1Mak heterozygotes, including neoplastic lesions in the breast, endometrium, prostate, adrenal gland, and lymphoid organs; tumor stage, grade, and metastatic potential are similar to that in Pten^tm1Mak heterozygotes

increased adrenal gland tumor incidence ( J:93530 )

increased lymphoma incidence ( J:93530 )

increased endometrial carcinoma incidence ( J:93530 )

♀

reproductive system

increased endometrial carcinoma incidence ( J:93530 )

♀