Phenotypes Associated with This Genotype

Genotype
MGI:3717654

• Allelic Composition: Agxt^tm1Ull/Agxt^tm1Ull
• Genetic Background: B6.129X1-Agxt^tm1Ull

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

hyperoxaluria ( J:117145 )

• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype

• urine oxalate levels increase in male mice treatment with ethylene glycol

crystalluria ( J:117145 )

• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice

nephrocalcinosis ( J:117145 )

• neprhocalcinosis develops in male mice after treatment with ethylene glycol

urolithiasis ( J:117145 )

• at 6 months, 62 of 112 male mice have stones in their urinary bladder

decreased creatinine clearance ( J:117145 )

• creatinine clearance is reduced in male mice treatment with ethylene glycol

kidney failure ( J:117145 )

• renal failure develops in male mice after treatment with ethylene glycol

homeostasis/metabolism

hyperoxaluria ( J:117145 )

• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype

• urine oxalate levels increase in male mice treatment with ethylene glycol

crystalluria ( J:117145 )

• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperoxaluria type 1		DOID:0111670	OMIM:259900	J:117145