growth/size/body
• at 23 days of age, animals are dwarfs with reduced body weights (6.7 grams) compared to heterozygous or non-transgenic littermates (11.1 grams)
|
behavior/neurological
• hydroencephaly is accompanied by lack of coordination
|
• hydroencephaly is accompanied by hunched posture
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nervous system
hydrocephaly
(
J:27781
)
• between 7 and 20 days after birth, all mice develop hydroencephaly
|
• lateral, third, and fourth ventricles are grossly enlarged; ependymal canal is severely enlarged
• foramina through which cerebrospinal fluid circulates remain open
|
• sylvian canal is enlarged
|
brain atrophy
(
J:27781
)
• brain regions adjacent to dilated cerebrospinal fluid spaces exhibit atrophy by compression
|
astrocytosis
(
J:27781
)
• mice show characteristic pattern of perivascular astrocytosis
|
• meningeal coverings are thicker than in hemizygotes or controls
|
immune system
N |
• no inflammatory cell infiltrates are seen in control mice or in transgenic mice displaying hydroencephaly
|