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Phenotypes Associated with This Genotype
Genotype
MGI:3717772
Allelic
Composition
Grxcr1pi/Grxcr1pi
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grxcr1pi mutation (1 available); any Grxcr1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• no evidence of auditory response at 21 to 30 days of age to sound
• can not swim on the surface of water or in a coordinated manner
• vertical movement of head with the nose maintained high momentarily
• whirling rapidly in circles of small diameter continuously for a long time by approximately 14 days of age
• no pronounced preference for right or left turning
• beginning at approximately 10 days of age mutant mice first display backing or crab-like movements
• occasional running in circles
• figure eight movements

hearing/vestibular/ear
• the hair cells and the supporting cells start to degenerate by two weeks of age
• although the organ of Corti develops normally, degeneration is found by the second week of life
• after two month
• the tectorial membrane is thickened at 12 days of age
• cristae ampullares degenerate after eight months of age
• by 6 th weeks
• macula of the utriculus remains unaffected
• cyclostat assessment suggests that these mutants do not develop rotational dizziness

nervous system
• the hair cells and the supporting cells start to degenerate by two weeks of age
• by four weeks of age
• a reduction of the average cell size in mice older than 200 days
• contains about the same number of cells and the range of cell sizes, however, there are much less large and more small cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory