Phenotypes Associated with This Genotype

Genotype
MGI:3718041

• Allelic Composition: Sv2b^tm1Baj/Sv2b^tm1Baj
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:70828 )

growth/size/body

decreased body size ( J:70828 )

nervous system

seizures ( J:70828 )

vision/eye

abnormal retina neuronal layer morphology ( J:148272 )

• expression of several synaptic vesicle proteins (v-glut1, Vamp2, Synaptotagim, Synaptophysin) is decreased in the retina

abnormal rod electrophysiology ( J:148272 )

• b-wave amplitudes, which reflect synaptic transmission between photoreceptors and bipolar neurons, are reduced about 30% at stimulus intensities that only rod photoreceptors are activated

• normalization to a-waves indicates an even greater reduction of 50% at the highest stimulation indices