Phenotypes for Tnfsf13b MGI:3718130 MGI Mouse

immune system

decreased T cell proliferation ( J:92334 )

• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13c^{Bcmd1-A/WySnJ} homozygotes

• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A

decreased B cell number ( J:138560 )

• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen

• MHC-mismatched allograft survival is marginally increased compared to in wild-type mice

• MHC-mismatched allograft survival is considerably increased with the use of cyclosporine A compared to wild-type and Igh-6^tm1Cgn homozygotes

hematopoietic system

decreased T cell proliferation ( J:92334 )

• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13c^{Bcmd1-A/WySnJ} homozygotes

• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A

decreased B cell number ( J:138560 )

• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen

cellular

decreased T cell proliferation ( J:92334 )

• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13c^{Bcmd1-A/WySnJ} homozygotes

• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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