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Phenotypes Associated with This Genotype
Genotype
MGI:3719236
Allelic
Composition		 Tcf4tm1Hmb/Tcf4tm1Zhu
Tg(Kit-cre)143Hmb/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4tm1Hmb mutation (0 available); any Tcf4 mutation (58 available)
Tcf4tm1Zhu mutation (0 available); any Tcf4 mutation (58 available)
Tg(Kit-cre)143Hmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected
abnormal B cell differentiation ( J:65236 )
• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
decreased double-positive T cell number ( J:65236 )
• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
spleen hypoplasia ( J:65236 )
• fewer splenocytes with the Tcf4tm1Hmb allele are detected

immune system
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected
abnormal B cell differentiation ( J:65236 )
• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
decreased double-positive T cell number ( J:65236 )
• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
spleen hypoplasia ( J:65236 )
• fewer splenocytes with the Tcf4tm1Hmb allele are detected

endocrine/exocrine glands
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory