Phenotypes Associated with This Genotype

Genotype
MGI:3719994

• Allelic Composition: Grb2^tm2Paw/Grb2^tm2Paw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:69138 )

• although mice develop to term none survive to P1

embryo

decreased placental labyrinth size ( J:69138 )

• placental labyrinth is reduced

craniofacial

abnormal mandible morphology ( J:69138 )

• in 3 of 22 mice

palatal shelves fail to meet at midline ( J:69138 )

• in newborns, palatal shelves remain cleft

cleft secondary palate ( J:69138 )

skeleton

abnormal mandible morphology ( J:69138 )

• in 3 of 22 mice

cardiovascular system

hemorrhage ( J:69138 )

• at E13.5 to E14.5, 6 of 22 mice are hemorrhagic or edemic

growth/size/body

palatal shelves fail to meet at midline ( J:69138 )

• in newborns, palatal shelves remain cleft

cleft secondary palate ( J:69138 )

decreased body length ( J:69138 )

• mice are smaller (2.43+/-0.15 cm) compared to wild-type mice (2.80+/-0.12 cm)

homeostasis/metabolism

edema ( J:69138 )

• at E13.5 to E14.5, 6 of 22 mice are hemorrhagic or edemic

digestive/alimentary system

palatal shelves fail to meet at midline ( J:69138 )

• in newborns, palatal shelves remain cleft

cleft secondary palate ( J:69138 )

behavior/neurological

absent gastric milk in neonates ( J:69138 )