Phenotypes Associated with This Genotype

Genotype
MGI:3719995

• Allelic Composition: Grb2^tm1Paw/Grb2^tm2Paw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69138 )

• by E11.5 mice are no longer viable

embryo

absent second pharyngeal arch ( J:69138 )

• at E9 to E10

decreased placental labyrinth size ( J:69138 )

• placental labyrinth is reduced

failure of chorioallantoic fusion ( J:69138 )

• at E9.5 to E10.5, chorioallantoic fusion fails to occur in 32% of mice

cardiovascular system

abnormal heart development ( J:69138 )

hearing/vestibular/ear

abnormal otic vesicle development ( J:69138 )

• large clusters of pycnotic nuclei are present in greater numbers (n=15) in the otic vesicle than in wild-type mice (n=11)

• mesenchyme cells in the otic vesicle undergo more apoptosis than in wild-type mice

nervous system

abnormal facial nerve morphology ( J:69138 )

• cranial nerve VII wanders at the dorsal body edge

abnormal vagus nerve morphology ( J:69138 )

• disorganized

craniofacial

absent second pharyngeal arch ( J:69138 )

• at E9 to E10