Phenotypes Associated with This Genotype

Genotype
MGI:3720390

• Allelic Composition: Tg(APOE-DGAT2)24Far/0
• Genetic Background: involves: C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

enlarged liver ( J:124005 )

• resulting from steatosis; liver weight to body weight ratio (0.047) is higher than in wild-type mice

hepatic steatosis ( J:124005 )

• steatosis exhibited by increase in size and paleness of livers

pale liver ( J:124005 )

• due to lipid deposits resulting from steatosis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:124005 )

N • food intake and body composition are not altered compared to wild-type animals

N • plasma levels of adipokines and inflammatory cytokines are similar to wild-type mice

N • blood glucose and insulin levels are similar to wild-type mice; transgenic mice do not display differences in glucose or insulin tolerance so mice are not insulin resistant

N • following feeding of a high-fat diet for 16 weeks, transgenic and control mice show similar degree of impairment of glucose tolerance and insulin resistance

increased circulating alanine transaminase level ( J:124005 )

• plasma transaminase levels are slightly elevated relative to wild-type

increased circulating aspartate transaminase level ( J:124005 )

• plasma transaminase levels are slightly elevated relative to wild-type

abnormal lipid level ( J:124005 )

• tissue content of diacylglycerol and ceramides are increased in liver; ; however, levels in skeletal muscle are not altered

decreased circulating triglyceride level ( J:124005 )

• plasma triglyceride levels in fasted mice are decreased by >65% relative to controls

abnormal fatty acids level ( J:124005 )

• content of unsaturated long-chain fatty acyl-CoAs are increased in the liver, but levels of saturated long-chain fatty acyl-CoAs are not

decreased circulating free fatty acids level ( J:124005 )

• plasma levels are slightly decreased relative to wild-type

increased triglyceride level ( J:124005 )

• triglyceride content is increased ~5-fold over wild-type

growth/size/body

enlarged liver ( J:124005 )

• resulting from steatosis; liver weight to body weight ratio (0.047) is higher than in wild-type mice