Phenotypes Associated with This Genotype

Genotype
MGI:3721136

• Allelic Composition: Siglec1^{tm1(HBEGF)Mtka}/Siglec1^{tm1(HBEGF)Mtka}; 1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal metallophilic macrophage morphology ( J:123958 )

• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent

abnormal spleen marginal zone macrophage morphology ( J:123958 )

• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent

abnormal immune system physiology ( J:123958 )

abnormal macrophage physiology ( J:123958 )

• following diptheria toxin (DT) treatment, clearance of injected apoptotic cells injected into the spleen is delayed

abnormal dendritic cell physiology ( J:123958 )

• following diptheria toxin (DT) treatment, more Itgax+ dendritic cells phagocytose apoptotic cells than in wild-type mice

• following diptheria toxin (DT) treatment, the antigen presenting ability of Itgax+ dendritic cells is increased relative to in wild-type mice

abnormal immune tolerance ( J:123958 )

• following diptheria toxin (DT) treatment, induction of tolerance fails

hematopoietic system

abnormal metallophilic macrophage morphology ( J:123958 )

• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent

abnormal spleen marginal zone macrophage morphology ( J:123958 )

• following diptheria toxin (DT) treatment, metallophilic macrophages and marginal zone macrophages are absent

abnormal macrophage physiology ( J:123958 )

• following diptheria toxin (DT) treatment, clearance of injected apoptotic cells injected into the spleen is delayed