Phenotypes Associated with This Genotype

Genotype
MGI:3721901

• Allelic Composition: Hoxa13^tm2Ipc/Hoxa13^tm2Ipc; Hoxd13^tm1Ddu/Hoxd13^tm1Ddu
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:36214 )

• pups die between E11.5 and E15.5 similar to in Hoxa13^tm2Ipc homozygotes

limbs/digits/tail

abnormal autopod morphology ( J:36214 )

• at E12.5 to E14.5, autopods are round with no external sign of digit formation and are more truncated than in any Hoxa13^tm2Ipc and/or Hoxd13^tm1Ddu mice

• at E14.5, chondrogenic activity is diffuse throughout the hindlimb autopods and in two ill-defined areas in the forelimb autopods

• in one mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula

short radius ( J:36214 )

• in three mouse that survived to E16.5

short ulna ( J:36214 )

• in three mouse that survived to E16.5

abnormal fibula morphology ( J:36214 )

• in three mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula

short limbs ( J:36214 )

growth/size/body

decreased embryo size ( J:36214 )

skeleton

short radius ( J:36214 )

• in three mouse that survived to E16.5

short ulna ( J:36214 )

• in three mouse that survived to E16.5

abnormal fibula morphology ( J:36214 )

• in three mouse that survived to E16.5, in the hindlimb there is a cartilage connection between the autopod and fibula

embryo

decreased embryo size ( J:36214 )