Phenotypes Associated with This Genotype

Genotype
MGI:3721959

• Allelic Composition: Zbtb17^tm1Cksn/Zbtb17^tm1Cksn; Krt14^tm1(cre)Wbm/Krt14⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

darkened coat color ( J:123966 )

• at one year of age mice have darker coat and skin than wild-type mice

• in areas of substantial hair loss a black dot-like area is visible

• light-tipped zigzag hairs are decreased in number

abnormal hair follicle melanocyte morphology ( J:123966 )

• back skin displays abnormal content distribution of melanin

• in areas of substantial hair loss a black dot-like area is visible

• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content

integument

increased keratinocyte proliferation ( J:123966 )

• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation

• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased

abnormal coat/ hair morphology ( J:123966 )

darkened coat color ( J:123966 )

• at one year of age mice have darker coat and skin than wild-type mice

• in areas of substantial hair loss a black dot-like area is visible

• light-tipped zigzag hairs are decreased in number

abnormal hair follicle melanocyte morphology ( J:123966 )

• back skin displays abnormal content distribution of melanin

• in areas of substantial hair loss a black dot-like area is visible

• mice exhibit focal areas in the dermis and subcutis around hair follicles with high melanin content

focal dorsal hair loss ( J:123966 )

• mice experience hair loss on the back skin without a reduction in the number of hair follicles

sparse hair ( J:123966 )

• hair density is decreased

rough coat ( J:123966 )

• 100% of mice have rough fur

• initially rough areas appear in stripes

decreased curvature of zigzag hairs ( J:123966 )

decreased zigzag hair amount ( J:123966 )

• only 24% to 54% of hairs are of the zigzag type compared to 70% in wild-type mice

abnormal hair follicle morphology ( J:123966 )

• hair follicle length is highly variable relative to in wild-type mice

• cyst-like hair follicles containing hair remnants are observed in some areas

• cystic alterations occur in the upper part of the follicle and epithelium of the cyst-like structure is continuous with the epidermis

• the number of hair follicles extending into the subcutis is increased relative to in wild-type mice

• catagen during the hair cycle is delayed

• at one year of age, numerous back skin hair follicles are thickened

abnormal hair follicle orientation ( J:123966 )

• the orientation of hair follicles is altered relative to in wild-type mice

abnormal epidermal layer morphology ( J:123966 )

• the number of interfollicular epidermal layers is increased

hyperkeratosis ( J:123966 )

cellular

increased keratinocyte proliferation ( J:123966 )

• keratinocyte located at the orifice of the hair funnel exhibit increased proliferation

• proliferation of keratinocyte in the anagen but not the catagen of the hair cycle is increased