Phenotypes Associated with This Genotype

Genotype
MGI:3722073

• Allelic Composition: Tap1^tm1Arp/Tap1^tm1Arp
• Genetic Background: B6.129S2-Tap1^tm1Arp/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

immune system

increased T-helper 1 cell number ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:123934 )

• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)

decreased susceptibility to bacterial infection ( J:123934 )

• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice

• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

hematopoietic system

increased T-helper 1 cell number ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:123934 )

• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)