Phenotypes for B2m MGI:3722074 MGI Mouse

increased susceptibility to infection induced morbidity/mortality ( J:123934 )

• following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose

increased T-helper 1 cell number ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:123934 )

• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)

• in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice

decreased IgG level ( J:110885 )

increased IgM level ( J:110885 )

abnormal interleukin level ( J:123934 )

• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice

abnormal tumor necrosis factor level ( J:123934 )

• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice

decreased susceptibility to autoimmune diabetes ( J:135214 )

• mice do not develop spontaneous diabetes compared to wild-type NOD controls

• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for about 17 weeks before developing hyperglycemia/diabetes; kinetics are much slower than in B2m-null, Tg(GFAP-B2m)Mdos (line 9 or 14) transgenic mice

decreased susceptibility to bacterial infection ( J:123934 )

• mice are highly resistant to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) following infection with either a low or high dose of IOE, 90% of mice survive a low dose with mild illness and all mice succumb to a high dose

• following infection with IEO, CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)

• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice

• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity