Phenotypes for Itgal MGI:3722098 MGI Mouse

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• reduced IL-2-activated NK cytotoxicity against tumor cell lines

• impaired binding (conjugate formation) to target cells

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

increased circulating interleukin-10 level ( J:123460 )

• serum levels of IL-10 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

increased circulating interleukin-2 level ( J:123460 )

• serum levels of IL-2 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

increased circulating tumor necrosis factor level ( J:123460 )

• serum levels of TNF-alpha levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

decreased susceptibility to endotoxin shock ( J:123460 )

• mice are resistant to death induced by up to 1000 times the normally lethal dose of LPS

• mice fail to exhibit liver injury in response to low doses of LPS with only marginal signs of apoptosis at 8 hours compared to wild-type mice that exhibit hepatocyte destruction at 6 hours

• TNF-alpha, IL-2 and IL-10 levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

• following treatment with a lose dose of LPS, platelet levels fail to increase as much as in heterozygous mice