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Phenotypes Associated with This Genotype
Genotype
MGI:3722099
Allelic
Composition
Itgaltm1Mak/Itgal+
Genetic
Background
B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours
• mice exhibit a delay in the onset of liver injury in response to low doses of LPS with injury levels at 8 hours comparable to those seen at 6 hours in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory