Phenotypes for E2f4 E2f5 MGI:3722671 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	E2f4^tm1Jrn/E2f4^tm1Jrn E2f5^tm1Dli/E2f5^tm1Dli
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4^tm1Jrn mutation (0 available); any E2f4 mutation (21 available)
E2f5^tm1Dli mutation (1 available); any E2f5 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:64757 )

• no homozygotes are identified at birth, however the expected numbers are seen at E13.5-E14.5

cellular

abnormal cell cycle ( J:64757 )

• isolated embryonic fibroblasts proliferate normally and re-enter from G0 with normal kinetics, however they fail to arrest in G1 in response to Cdkn2a (p16^INK4a)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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