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Phenotypes Associated with This Genotype
Genotype
MGI:3722916
Allelic
Composition		 E2f2tm1Zubi/E2f2tm1Zubi
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (60 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina ganglion cell number ( J:124204 )
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice
decreased retina rod cell number ( J:124204 )
• apoptosis eliminates many rod cells as in Rbl1 null mice
abnormal retina bipolar cell morphology ( J:124204 )
• apoptosis eliminates most bipolar cells as in Rbl1 null mice
abnormal eye development ( J:124204 )
• retinal transition cells (RTC) undergo ectopic cell divisions as in Rbl1 null mice

nervous system
decreased retina ganglion cell number ( J:124204 )
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice
decreased retina rod cell number ( J:124204 )
• apoptosis eliminates many rod cells as in Rbl1 null mice
abnormal retina bipolar cell morphology ( J:124204 )
• apoptosis eliminates most bipolar cells as in Rbl1 null mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory