Phenotypes Associated with This Genotype

Genotype
MGI:3722920

• Allelic Composition: E2f3^tm1.1Gle/E2f3^tm1.1Gle; Rbl1^tm1Htr/Rbl1^tm1Htr; Tg(Pax6-cre,GFP)2Pgr/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina ganglion cell number ( J:124204 )

• apoptosis eliminates most retinal ganglion cells

decreased retina rod cell number ( J:124204 )

• apoptosis eliminates many rod cells

abnormal amacrine cell morphology ( J:124204 )

• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis

• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells

• however, markers of SAC differentiation are restored

abnormal retina bipolar cell morphology ( J:124204 )

• apoptosis eliminates most bipolar cells

abnormal eye development ( J:124204 )

• retinal transition cells (RTC) undergo ectopic cell divisions

• however, markers of starburst amacrine cell differentiation are restored

nervous system

decreased retina ganglion cell number ( J:124204 )

• apoptosis eliminates most retinal ganglion cells

decreased retina rod cell number ( J:124204 )

• apoptosis eliminates many rod cells

abnormal amacrine cell morphology ( J:124204 )

• however, markers of SAC differentiation are restored

• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells

• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis

abnormal retina bipolar cell morphology ( J:124204 )

• apoptosis eliminates most bipolar cells