Phenotypes Associated with This Genotype

Genotype
MGI:3723121

• Allelic Composition: Fts/Fts
• Genetic Background: involves: C3H * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:79899 )

• survival improves to about E14.5, compared to 9.5-12.5 on a B6/NMRI background

embryonic lethality, complete penetrance ( J:168037 )

• mice die by E13.5

limbs/digits/tail

abnormal autopod morphology ( J:79899 )

• accumulation of cells at the distal tip of autopods

• anterior mesoderm development is aborted

• abnormal joint development

abnormal digit morphology ( J:79899 )

hindlimb oligodactyly ( J:79899 )

• hind limb digits 1 or 1 and 2 are missing

polydactyly ( J:79899 )

• dorso-ventral metacarpal duplication apparent in forelimbs at E12.5

• anterior-posterior polydactyly seen on occasion

abnormal forelimb zeugopod morphology ( J:79899 )

• radius and ulna shortened and bent

abnormal hindlimb zeugopod morphology ( J:79899 )

• tibia absent

abnormal limb development ( J:79899 )

abnormal limb bud morphology ( J:79899 )

• extreme proximal-distal shortening

• truncations apparent at E13.5

abnormal apical ectodermal ridge morphology ( J:79899 )

• premature degeneration

abnormal digit development ( J:79899 )

• digital anlagen completely lack phalangeal elements in forelimbs

• only metacarpals in forelimbs

• development of posterior digits is normal

embryo

abnormal limb bud morphology ( J:79899 )

• extreme proximal-distal shortening

• truncations apparent at E13.5

abnormal apical ectodermal ridge morphology ( J:79899 )

• premature degeneration

endocrine/exocrine glands

abnormal ovary morphology ( J:168037 )

♀ • germ cells are present in isolation unlike in wild-type mice

reproductive system

decreased germ cell number ( J:168037 )

• in male and female mice at E12.5

decreased primordial germ cell proliferation ( J:168037 )

• primordial germ cell (PGC) proliferation is progressively lost unlike in wild-type mice

• however, PGC apoptosis is normal

abnormal ovary morphology ( J:168037 )

♀ • germ cells are present in isolation unlike in wild-type mice

cellular

decreased germ cell number ( J:168037 )

• in male and female mice at E12.5

decreased primordial germ cell proliferation ( J:168037 )

• primordial germ cell (PGC) proliferation is progressively lost unlike in wild-type mice

• however, PGC apoptosis is normal