Phenotypes Associated with This Genotype

Genotype
MGI:3723123

• Allelic Composition: Fts/Fts⁺
• Genetic Background: B6.Cg-Fts

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:108193 )

• resulting from heart failure or pneumonia

immune system

thymus hyperplasia ( J:108193 )

• apparent at 4-5 weeks of age

• plateaus at 10 weeks of age

• 86 fold increase in thymocytes at peak

• lower frequency of emigration from thymus

abnormal T cell morphology ( J:108193 )

increased thymocyte number ( J:108193 )

• 86 fold increase in thymocytes at peak

abnormal CD4-positive T cell differentiation ( J:108193 )

• decreased conversion of double positive T cells to CD4 positive cells

abnormal T cell physiology ( J:108193 )

• thymocytes show a reduced susceptibility to apoptosis

respiratory system

respiratory distress ( J:108193 )

• dyspnea

hematopoietic system

thymus hyperplasia ( J:108193 )

• apparent at 4-5 weeks of age

• plateaus at 10 weeks of age

• 86 fold increase in thymocytes at peak

• lower frequency of emigration from thymus

abnormal T cell morphology ( J:108193 )

increased thymocyte number ( J:108193 )

• 86 fold increase in thymocytes at peak

abnormal CD4-positive T cell differentiation ( J:108193 )

• decreased conversion of double positive T cells to CD4 positive cells

abnormal T cell physiology ( J:108193 )

• thymocytes show a reduced susceptibility to apoptosis

endocrine/exocrine glands

thymus hyperplasia ( J:108193 )

• apparent at 4-5 weeks of age

• plateaus at 10 weeks of age

• 86 fold increase in thymocytes at peak

• lower frequency of emigration from thymus

increased thymocyte number ( J:108193 )

• 86 fold increase in thymocytes at peak