Phenotypes Associated with This Genotype

Genotype
MGI:3723514

• Allelic Composition: Mapkapk5^tm1Pqs/Mapkapk5⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:117893 )

• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5^tm1Pqs homozygotes

• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment

• only one papilloma progressed to malignant carcinoma 5 months after detection

• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection

• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium

• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors

• however, untreated mice are healthy and tumor-free for at least 2 years

cellular

delayed cellular replicative senescence ( J:117893 )

• mouse skin fibroblast cells derived from mice express less ras-induced senescence markers than wild-type DMBA-induced tumors

integument

increased skin papilloma incidence ( J:117893 )

• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5^tm1Pqs homozygotes

• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment

• only one papilloma progressed to malignant carcinoma 5 months after detection

• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection

• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium

• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors

• however, untreated mice are healthy and tumor-free for at least 2 years