mortality/aging
• fewer than expect mice survive to weaning
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reproductive system
• while immature spermatpgonia is detected all mature spermtocytes are pyknotic
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• irregardless of the genotype of the females, male mice never sire offspring
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hematopoietic system
• the number of B220+ CD43+ pro-B cells are increased 2-fold relative to in wild-type mice
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• mice exhibit an increase in the ratio of CD4+ to CD8+ T cells in the lymph nodes relative to wild-type mice
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• bone marrow cell number is reduced to 50% of that observed in wild-type mice
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• 6.5+/-2.0 x109/ml compared to 8.0+/-0.62x109/ml in Pgm3mld1 homozygotes and 10.4+/-0.5 x109/ml in wild-type mice
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• 37.9+/-10.9% compared to 45.8+/-3.0% in Pgm3mld1 homozygotes and 53.2+/-2.4% in wild-type mice
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• 858+/-312x106/ml compared to 620+/-128x106/ml in Pgm3mld1 homozygotes and 1159+/-176x106/ml in wild-type mice
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• 4.8+/-2.1x106/ml compared to 3.7+/-1.3x106/ml in Pgm3mld1 homozygotes and 9.2+/-1.9x106/ml in wild-type mice
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• the frequency and number of B cells at all later stages of maturation is reduced and the B cell number in the peritoneal cavity and peripheral lymphoid organs is reduced
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• lymphoid follicles are absent
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• the number of T cells in the spleen is moderately to severely reduced compared to in wild-type mice
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digestive/alimentary system
• acini are reduced in size and dispersed
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• protein fecal content is increased relative to in wild-type mice
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• salivary gland architecture is disrupted
• cells are reduced in size and dispersed
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renal/urinary system
• mice exhibit glomerulonephritis with amorphous material filling the glomeruli
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immune system
• the number of B220+ CD43+ pro-B cells are increased 2-fold relative to in wild-type mice
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• mice exhibit an increase in the ratio of CD4+ to CD8+ T cells in the lymph nodes relative to wild-type mice
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• 4.8+/-2.1x106/ml compared to 3.7+/-1.3x106/ml in Pgm3mld1 homozygotes and 9.2+/-1.9x106/ml in wild-type mice
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• the frequency and number of B cells at all later stages of maturation is reduced and the B cell number in the peritoneal cavity and peripheral lymphoid organs is reduced
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• lymphoid follicles are absent
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• the number of T cells in the spleen is moderately to severely reduced compared to in wild-type mice
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• mice exhibit glomerulonephritis with amorphous material filling the glomeruli
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endocrine/exocrine glands
• salivary gland architecture is disrupted
• cells are reduced in size and dispersed
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• pancreatic architecture is disrupted
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• acini are reduced in size and dispersed
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