Phenotypes Associated with This Genotype

Genotype
MGI:3758875

• Allelic Composition: Il7r^tm1Imx/Il7r^tm1Imx
• Genetic Background: B6.129S7-Il7r^tm1Imx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:125360 )

• thymic cellularity is severely decreased

• at all double negative stages, reduction in thymocytes is more severe than in Il7r^tm1Abra homozygotes

abnormal T cell differentiation ( J:125360 )

• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice

• double negative cell development is blocked at stage IV

• CD4+ and CD8+ T cell development is severely disrupted

decreased double-positive T cell number ( J:125360 )

• mice have less double positive thymocytes than Il7r^tm1Abra homozygotes

immune system

decreased thymocyte number ( J:125360 )

• thymic cellularity is severely decreased

• at all double negative stages, reduction in thymocytes is more severe than in Il7r^tm1Abra homozygotes

abnormal T cell differentiation ( J:125360 )

• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice

• double negative cell development is blocked at stage IV

• CD4+ and CD8+ T cell development is severely disrupted

decreased double-positive T cell number ( J:125360 )

• mice have less double positive thymocytes than Il7r^tm1Abra homozygotes

endocrine/exocrine glands

decreased thymocyte number ( J:125360 )

• thymic cellularity is severely decreased

• at all double negative stages, reduction in thymocytes is more severe than in Il7r^tm1Abra homozygotes