Phenotypes Associated with This Genotype

Genotype
MGI:3758888

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm3Zuk; Inhbb^tm1Jae/Inhbb^tm1Jae; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

absent oocytes ( J:125354 )

♀ • 2 of 4 females produce no oocytes upon superovulation

♀ • however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

reproductive system

absent oocytes ( J:125354 )

♀ • 2 of 4 females produce no oocytes upon superovulation

♀ • however, there is no difference in the number of oocytes superovulated in the remaining 2 mice

increased corpora lutea number ( J:125354 )

♀ • at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

female infertility ( J:125354 )

♀ • females are infertile

growth/size/body

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

homeostasis/metabolism

increased follicle stimulating hormone level ( J:125354 )

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

♀ • at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

abnormal ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present

abnormal tertiary ovarian follicle morphology ( J:125354 )

♀ • between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

ovarian follicular cyst ( J:125354 )

♀ • at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker

increased ovary weight ( J:125354 )

♀ • by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhba^tm1Zuk/Inhba^tm3Zuk mice)