Phenotypes for Inhba Inhbb MGI:3758893 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Inhba^tm1Zuk/Inhba^tm3Zuk Inhbb^tm1Jae/Inhbb^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm1Zuk mutation (2 available); any Inhba mutation (31 available)
Inhba^tm3Zuk mutation (1 available); any Inhba mutation (31 available)
Inhbb^tm1Jae mutation (3 available); any Inhbb mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:125354 )

• 3 of 5 females are infertile

reduced female fertility ( J:125354 )

• the number of litters produced by females is reduced 43% (0.10+/-0.07 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (1.00+/-0.63 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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