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Phenotypes Associated with This Genotype
Genotype
MGI:3758897
Allelic
Composition		 Smad2tm1Cxd/Smad2+
Smad3tm1Cxd/Smad3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm1Cxd mutation (0 available); any Smad2 mutation (52 available)
Smad3tm1Cxd mutation (0 available); any Smad3 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal Meckel's cartilage morphology ( J:76396 )
• E11 mandibular explants cultured in vitro form thinner Meckel's cartilage and show a developmental delay

skeleton
abnormal Meckel's cartilage morphology ( J:76396 )
• E11 mandibular explants cultured in vitro form thinner Meckel's cartilage and show a developmental delay

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory