Analysis Tools
cardiovascular system
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• neointimal hyperplasia is enhanced in response to arterial injury compared to wild-type
• intima contains more proliferating smooth muscle cells with less collagen deposition than in wild-type
• growth of intimal smooth muscle cells (SMC) is only weakly inhibited by TGF-beta in vitro compared to wild-type, however chemotaxis of SMC towards TGF-beta is normal
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homeostasis/metabolism
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• neointimal hyperplasia is enhanced in response to arterial injury compared to wild-type
• intima contains more proliferating smooth muscle cells with less collagen deposition than in wild-type
• growth of intimal smooth muscle cells (SMC) is only weakly inhibited by TGF-beta in vitro compared to wild-type, however chemotaxis of SMC towards TGF-beta is normal
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• at 14 days after unilateral ureteral obstruction (UUO), the mutant obstructed kidney shows attenuated scar formation, and decreased renal interstitial fibrosis, inflammation and apoptosis relative to the wild-type obstructed kidney
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renal/urinary system
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• prior to unilateral ureteral obstruction (UUO), 10 -12 week-old mutant mice exhibit histologically normal kidneys and normal serum blood urea nitrogen (BUN) and creatinine levels relative to wild-type controls
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• at 14 days after UUO, the number of TUNEL-positive tubular apoptotic cells is significantly reduced in the obstructed mutant kidney relative to that in wild-type controls
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• at 14 days after UUO, the numbers of F4/80-positive interstitial macrophages, and CD4-positive and CD8-positive interstitial cells are significantly reduced in the obstructed mutant kidney relative to that in wild-type controls
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• at 14 days after UUO, renal interstitial fibrosis is significantly attenuated in the obstructed mutant kidney relative to that in wild-type controls, as shown by Aniline-blue or Sirius red staining
• at 14 days after UUO, deposition of type I and type III collagens and the number of of alpha-SMA-positive interstitial myofibroblasts are significantly reduced in the obstructed mutant kidney relative to that in wild-type controls
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immune system
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• at 14 days after UUO, the numbers of F4/80-positive interstitial macrophages, and CD4-positive and CD8-positive interstitial cells are significantly reduced in the obstructed mutant kidney relative to that in wild-type controls
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cellular
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• at 14 days after UUO, the number of TUNEL-positive tubular apoptotic cells is significantly reduced in the obstructed mutant kidney relative to that in wild-type controls
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