Phenotypes for Smad3 MGI:3760247 MGI Mouse

increased intestinal adenocarcinoma incidence ( J:106572 )

• mutants maintained free of the gram-negative enterohepatic bacteria Helicobacter for up to 9 months do not develop colon cancer as do mutants housed under normal conditions

• infection of mutants with Helicobacter triggers colon cancer in 50-66% of mutants; mucinous adenocarcinomas develop 5 to 30 weeks after infection

abnormal circulating interleukin-6 level ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury (25 min in duration), homozygotes fail to exhibit a significant increase in plasma IL-6 levels, unlike similarly-treated wild-type controls

abnormal cytokine secretion ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury, homozygotes exhibit a significant reduction in the renal expression of IL-6 and endothelin-1 mRNA, unlike similarly-treated wild-type controls

• however, expression of other cytokines known to contribute to ischemic acute kidney injury is not significantly altered

decreased interleukin-6 secretion ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury, homozygotes exhibit a drastic reduction in renal expression of IL-6, unlike similarly-treated wild-type controls

increased inflammatory response ( J:106572 )

• colonic tissue of uninfected mutants is in a proinflammatory state as indicated by increased mRNA levels of IL-6, TNF-alpha, IFN-gamma, and IL-4, which is exacerbated by Helicobacter infection

decreased susceptibility to kidney reperfusion injury ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury (either 22.5 or 25 min in duration), homozygotes exhibit better preservation of renal function as measured by serum BUN and creatinine levels

• renal histological injury is significantly reduced as shown by decreased acute tubular necrosis, intratubular sloughing and cast formation

decreased circulating creatinine level ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury (either 22.5 or 25 min in duration), homozygotes exhibit significantly reduced serum creatinine levels relative to wild-type controls

decreased blood urea nitrogen level ( J:175290 )

• at 24 hrs after bilateral renal ischemia reperfusion (I/R) injury (either 22.5 or 25 min in duration), homozygotes exhibit significantly reduced serum BUN levels relative to wild-type controls