Phenotypes Associated with This Genotype

Genotype
MGI:3760992

• Allelic Composition: Unc5b^tm1Matl/Unc5b^tm1Matl
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:126240 , J:142510 )

• mice die at embryonic day 12.5 death due to heart failure from increased resistance from arterial vasculature (J:126240)

• Background Sensitivity: on a CD-1 mixed background, mice die at E13.5 compared to E10.5 for mice on a C57BL/6 background (J:142510)

embryo

embryonic growth arrest ( J:126240 )

• by embryonic day 12.5

cardiovascular system

abnormal capillary morphology ( J:126240 )

• in E12.5 embryos, capillaries in hindbrains and neural tubes are thinner, have 40% more branch points, and increased filopodial extensions

• capillary morphology does not change upon injection of netrin-1 protein in the hindbrain of E10.5 embryos

abnormal capillary branching pattern ( J:126240 )

• increase in branching points in the neural tube and hindbrain

abnormal vasculogenesis ( J:126240 )

• increased vessel branching of the internal carotid artery, intersomitic vessels, and blood vessels within the nervous system

cellular

abnormal apoptosis ( J:126240 )

• no decreases in apoptosis of endothelial cells, suggesting loss of gene regulates guidance and not survival

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:142510 )

N • mice exhibit normal inner ear formation