Phenotypes Associated with This Genotype

Genotype
MGI:3761088

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal gamma-delta T cell differentiation ( J:3865 )

• rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells ( J:3865 )

• gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control

hematopoietic system

abnormal gamma-delta T cell differentiation ( J:3865 )

• rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells ( J:3865 )

• gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control