About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3761094
Allelic
Composition		 Chek2tm1Mak/Chek2tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2tm1Mak mutation (1 available); any Chek2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ionizing radiation ( J:126186 )
• mouse embryonic fibroblast cells fail to undergo apoptosis following exposure to ionizing radiation as do wild-type cells
• however, mouse embryonic fibroblast cells arrest in G1 phase following exposure to ionizing radiation unlike Trp53 null cells and similar to wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory