Analysis Tools
immune system
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• B cell proliferation in response to anti-IgM is reduced 3- to 4-fold compared to in wild-type mice
• however, B cell proliferation in response to IL-4 alone or in combination with CD40LG or LPS is normal
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• T cell proliferation in response to anti-CD3-epsilon is reduced 5- to 8-fold compared to in wild-type mice
• T cell proliferation in response to ovalbmin is reduced 4- to 6-fold compared to in wild-type mice
• however, T cell proliferation in response to PHA is normal
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• the number of CD5+ B220+ T cells is slightly decreased (21.0+/-8.6% compared to 39.5+/-9.1% in wild-type mice)
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• IgG3 levels are slightly lower than in wild-type mice
• following challenge with ovalbumin, anti-ovalbumin IgG3 antibodies are lower than in similarly treated wild-type mice
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• following stimulation with TNP-Ficoll, anti-TNP IgM antibodies are 9-fold lower than in similarly treated wild-type mice
• following challenge with ovalbumin, anti-ovalbumin IgM antibodies are lower than in similarly treated wild-type mice
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• following in vitro stimulation with ovalbumin or anti-CD3 epsilon antibodies, cells produce less interferon-gamma than wild-type mice
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• following in vitro stimulation with ovalbumin or anti-CD3 epsilon antibodies, cells produce less IL-2
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• following in vitro stimulation with ovalbumin or anti-CD3 epsilon antibodies, cells produce more IL-4 than wild-type mice
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behavior/neurological
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• during passive avoidance testing, mice display more frequent urination and defecation and decreased movement compared to wild-type mice
• however, passive avoidance behavior is normal
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• despite normal motor coordination, mice exhibit decreased ambulation and time of rearing for the first 30 minutes when placed in a new environment
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• mice exhibit increased locomotor activity during early portions of the light phase and decreased ambulation during the dark phase of a 12 hours light 12 hour dark cycle relative to similarly treated wild-type mice
• the ratio of ambulation during the light phase to total ambulation during 24 hours is increased compared to in wild-type mice
• however, total ambulation during a 24 hours period is normal
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• mice rear less when placed in a new environment compared to wild-type mice
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hematopoietic system
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• B cell proliferation in response to anti-IgM is reduced 3- to 4-fold compared to in wild-type mice
• however, B cell proliferation in response to IL-4 alone or in combination with CD40LG or LPS is normal
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• T cell proliferation in response to anti-CD3-epsilon is reduced 5- to 8-fold compared to in wild-type mice
• T cell proliferation in response to ovalbmin is reduced 4- to 6-fold compared to in wild-type mice
• however, T cell proliferation in response to PHA is normal
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• the number of CD5+ B220+ T cells is slightly decreased (21.0+/-8.6% compared to 39.5+/-9.1% in wild-type mice)
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• IgG3 levels are slightly lower than in wild-type mice
• following challenge with ovalbumin, anti-ovalbumin IgG3 antibodies are lower than in similarly treated wild-type mice
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• following stimulation with TNP-Ficoll, anti-TNP IgM antibodies are 9-fold lower than in similarly treated wild-type mice
• following challenge with ovalbumin, anti-ovalbumin IgM antibodies are lower than in similarly treated wild-type mice
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cellular
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• B cell proliferation in response to anti-IgM is reduced 3- to 4-fold compared to in wild-type mice
• however, B cell proliferation in response to IL-4 alone or in combination with CD40LG or LPS is normal
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• T cell proliferation in response to anti-CD3-epsilon is reduced 5- to 8-fold compared to in wild-type mice
• T cell proliferation in response to ovalbmin is reduced 4- to 6-fold compared to in wild-type mice
• however, T cell proliferation in response to PHA is normal
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