Phenotypes Associated with This Genotype

Genotype
MGI:3762505

• Allelic Composition: Phox2a^{tm1(Phox2b)Mist}/Phox2a^{tm1(Phox2b)Mist}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:126634 )

N • neonatal lethality observed in mice lacking Phox2a and survive into adulthood

nervous system

nervous system phenotype ( J:126634 )

N • unlike in mice lacking Phox2a, sensory and autonomic ganglia, sphenopalatine ganglia and locus coeruleus develop normally

abnormal oculomotor nerve morphology ( J:126634 )

• at E13.5, fewer neurons are present than in wild-type mice

• at E18.5, the number of neurons is decreased by 87% of that found in wild-type mice

• however, remaining precursors migrate normally to the contralateral side and no defects in cell proliferation or apoptosis are detected

• no oculomotor nerve is present

abnormal trochlear nerve morphology ( J:126634 )

• at E13.5, fewer neurons are present than in wild-type mice

• at E18.5, the number of neurons is decreased by 50% of that found in wild-type mice

• the trochlear nerve is shorter than in wild-type mice

• however, no defects in cell proliferation or apoptosis were detected