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Phenotypes Associated with This Genotype
Genotype
MGI:3762928
Allelic
Composition		 Cblbtm1Pngr/Cblbtm1Pngr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Pngr mutation (6 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:126361 )
• greatly decreased rate of immunoglobulin receptor internalization
increased interleukin-6 secretion ( J:126361 )
• greatly enhanced levels produced by mast cells upon stimulation
increased tumor necrosis factor secretion ( J:126361 )
• greatly enhanced levels produced by mast cells upon stimulation

hematopoietic system
abnormal mast cell physiology ( J:126361 )
• greatly decreased rate of immunoglobulin receptor internalization

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory