Phenotypes Associated with This Genotype

Genotype
MGI:3764661

• Allelic Composition: Tg(APOC1)1Lmh/Tg(APOC1)1Lmh
• Genetic Background: C57BL/6-Tg(APOC1)1Lmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged heart ( J:65036 )

decreased body size ( J:65036 )

• mutants appear smaller, however weight at 2.5 months of age is similar to wild-type

enlarged liver ( J:65036 )

enlarged spleen ( J:65036 )

homeostasis/metabolism

increased circulating cholesterol level ( J:65036 )

increased circulating VLDL cholesterol level ( J:65036 )

• increases in cholesterol are mainly due to elevated VLDL levels

increased circulating free fatty acids level ( J:65036 )

increased circulating triglyceride level ( J:65036 )

increased circulating VLDL triglyceride level ( J:65036 )

• increases in triglycerides are mainly due to elevated VLDL levels

adipose tissue

absent subcutaneous adipose tissue ( J:65036 )

• skin lacks subcutaneous adipose tissue

abnormal abdominal fat pad morphology ( J:65036 )

• small abdominal fat pads

cardiovascular system

enlarged heart ( J:65036 )

hematopoietic system

enlarged spleen ( J:65036 )

immune system

enlarged spleen ( J:65036 )

folliculitis ( J:65036 )

• some mutants develop mild folliculitis

dermatitis ( J:65036 )

• at older ages, lesions develop into severe dermatitis, with a moderate epidermal hyperplasia with hyper- and parakeratosis

liver/biliary system

enlarged liver ( J:65036 )

vision/eye

abnormal eye morphology ( J:65036 )

• develop extensive crusts around the eyes

Meibomian gland atrophy ( J:65036 )

• meibomian glands lack the typical foamy appearance

integument

absent subcutaneous adipose tissue ( J:65036 )

• skin lacks subcutaneous adipose tissue

Meibomian gland atrophy ( J:65036 )

• meibomian glands lack the typical foamy appearance

sebaceous gland atrophy ( J:65036 )

• the cytoplasm of the atrophic sebaceous glands loses its foamy appearance

• the outer surface of the eyelids shows sebaceous gland atrophy

folliculitis ( J:65036 )

• some mutants develop mild folliculitis

dermatitis ( J:65036 )

• at older ages, lesions develop into severe dermatitis, with a moderate epidermal hyperplasia with hyper- and parakeratosis

alopecia ( J:65036 )

• hair loss becomes more severe upon aging, such that older mutants appear almost hairless

hyperkeratosis ( J:65036 )

• in older mutants

parakeratosis ( J:65036 )

• in older mutants

epidermal hyperplasia ( J:65036 )

• develops in older mutants

epidermal necrosis ( J:65036 )

• epidermis of older mice is necrotic with extensive infiltration of inflammatory cells

thick epidermis ( J:65036 )

dry skin ( J:65036 )

scaly skin ( J:65036 )

• fine epidermal scaling

skin lesions ( J:65036 )

• mutants exhibit skin lesions that vary from a mild folliculitis to a mild mixed cellular infiltration in the dermis

thick skin ( J:65036 )

increased pruritus ( J:65036 )

• develop pruritus

endocrine/exocrine glands

Meibomian gland atrophy ( J:65036 )

• meibomian glands lack the typical foamy appearance

sebaceous gland atrophy ( J:65036 )

• the cytoplasm of the atrophic sebaceous glands loses its foamy appearance

• the outer surface of the eyelids shows sebaceous gland atrophy