Phenotypes Associated with This Genotype

Genotype
MGI:3764960

• Allelic Composition: Apc^tm1.1Tno/Apc⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127452 )

• average lifespan is 22.5 weeks due to bowel obstructions and bleeding

neoplasm

increased intestinal adenoma incidence ( J:127452 )

• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine

digestive/alimentary system

gastrointestinal hemorrhage ( J:127452 )

• severe bleeding often is cause of death

intestine polyps ( J:127452 )

• occurring frequently in the jejunum and ileum

increased intestinal adenoma incidence ( J:127452 )

• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine

intestinal obstruction ( J:127452 )

• resulting from the numerous polyps in the small intestines

• major cause of death by 22.5 weeks of age

hematopoietic system

anemia ( J:127452 )

• resulting from intestinal bleeding

cardiovascular system

gastrointestinal hemorrhage ( J:127452 )

• severe bleeding often is cause of death